Stomatitis, an inflammatory disorder of the oral mucosa, presents with symptoms such as pain, ulcers, redness, and swelling, significantly impacting daily activities like eating and speaking. This article provides a comprehensive overview, integrating modern medical insights with the Ayurvedic perspective on Mukhpak, a analogous condition attributed to Pitta dosha vitiation often exacerbated by dietary habits, stress, or toxins. The introduction delineates the condition's prevalence and significance, while the review of types categorizes stomatitis into aphthous, herpetic, candidal, and others, paralleling Ayurvedic classifications like Vataja, Pittaja, and Kaphaja Mukhpak. Existing treatments are explored: modern approaches include antivirals (e.g., acyclovir), corticosteroids, and antimicrobial rinses for symptomatic relief and infection control, whereas Ayurveda emphasizes detoxification via Virechana, herbal applications like honey-turmeric paste, and procedures such as Gandusha with Triphala for balancing doshas and promoting healing. Complications discussed range from secondary infections and nutritional deficits in modern views to systemic imbalances like aggravated Pitta leading to digestive issues in Ayurveda. The discussion highlights the synergy between both systems, noting Ayurveda's strength in prevention and recurrence reduction through holistic methods, supported by case studies, though calling for more randomized trials. In conclusion, an integrative approach offers optimal management, emphasizing early detection and lifestyle adjustments.