Panchakarma is very important chikitsa karma in ayurveda. Vaman, Virechan, Basti, Natsya and Raktamokshan together known as Panchakarma in todays practice. In acute and emergency conditions, karmas included in Panchakarma become very important to achieve tatkal upashaya as they are employed to remove prakupit Doshas rapidly. Vaman is useful to remove prakupit Kapha dosha from body,  Virechan Is useful to remove prakupit  Pitta dosha, Basti is used to treat prakupit Vata dosha, Natsya is useful to treat 'Urdhva Jatrugat vyadhies’  caused by prakupita doshas and Raktamokshana is useful to remove dushit Rakta to treat ‘Rakta dushti janya vyadhi’. This article evaluates the role of Vamana, Virechan, Basti, Raktamokshana and Natsya karma in stabilizing patients during life-threatening crises such as acute poisoning, respiratory distress, and neurological collapse. Panchakarma provides a rapid physiological response as it expelled out the cause i.e. prakupit doshas responsible for that emergency.