A chemical that appears in an organism but is not generated or expected to be present there naturally is called a xenobiotic. It might be a dangerous foreign substance that entered the body in minute amounts to prevent the person from dying right away. Tobacco and other drugs that leave behind residues that are not fully metabolized, as well as environmental contaminants like soil, air or water pollunts like industrial residues, food additives, food taste enhancers and food coloring like MSG, Hydrocarbon containing products and pesticide residue in food like raw fruits and vegetables are the example of xenobiotics. routes including ingestion, inhalation and skin surface absorption can allow xenobiotics to enter the body. In Ayurvedic classic, the term Gara Visha gives us a clear understanding of these tiny amounts of toxins. Agadtantra which is one of the branch of Ashtang Ayurveda has given more emphasis over Garavisha (Artificial Poison). Gara Visha formed by combination of two or more than two poisonous or non -poisonous drugs and ultimately affect the whole body by viating all Dhatus in the body. Now a days People unknowingly consume these xenobiotics substance. this paper highlight the role of xenobiotics with special reference to Gara Visha and its preventive management.