Amavata is particular type of disease that is mentioned in Ayurveda since the period of Madhavkar, under the category of Vata-Kaphaja disorder.The term Ama ordinarily means, unripe, uncooked, immature undigested substance. It is produced from the impaired function of the kayangni. It is a toxic substance of gastroenteric origin.Vata is the chief functional operator of the all types of voluntary or involuntary movements of body. Vitiated Vata Dosha along with Ama is termed as Amavata. It indicates the propulsion of Ama by vitiated Vata throughout body getting lodge in Sandhisthana (joint areas) producing Amavata. Amavata is such a disease of chronic joint pain and body ache, accompanied by swelling of some or all of the Synovial joints. Angamarda,  Aruchi, Trishna, Alasya, Gourav, Klama, Apaka and Fever. Amavata can be correlated with Rheumatoid Arthritis. In Amavata Vata as a Dosha and Ama are chief pathogenic factor. They are exactly opposite in the properties so difficult to treat. It is the disease of Madhyam margag roga and having Chirkari Swabhava, sometimes it can also be manifested as the acute case. Chakradatta was first to describe in the treatment for Amavata. He gave Basti chikitsa especially Vaitaran Basti is considered as the chief treatment regimen for Amavata. Amavata Pramathini Vati is one of the formulation which is prescribed to treat Amavata. The description of Amavata Pramathini Vati is found in Bhaishajya Ratnavali. Amavata Pramathini Vati is a formulation of five drugs Kalmishora, Arkamula, Shuddha Gandhaka, Lohabhasma and Abhrakbhasma. These drugs play significant role in reducing the symptoms and to treat the Amavata. The drugs have VataKaphaghna property which reduce Vata and Kapha Doshas from the body and reduces the symptoms of Amavata.